미국 Harvard Medical School의 Arlene Sharpe 교수님 방문 세미나를 개최합니다.
immunologist, tumor microenvironment 등 유관 분야 연구자들의 많은 관심과 참여를 부탁드립니다.
1. 일시 : 2025년 2월 6일(목) 11:00 ~ 12:30
※ 점심 식사를 같이 하실 분이나 이후 따로 만나실 분들은 이현숙 교수님(hl212@snu.ac.kr)께 별도 연락 바랍니다.
2. 장소 : 유전공학연구소 서관 1층 강당
3. 연사 소개 : 상세 내용 첨부 파일 참조
Sharpe 교수님의 발견을 근거로 immune checkpoint blackade의 개발과 노벨상이 가능했음
- T Cell Co-stimulatory, Co-inhibitory mechanism 발견
- 남편인 Freedman의 CRISPR screening을 통해 PD1과 CTLA4등 immune checkpoint 발견
4. 세미나 타이틀 및 초록 : Overcoming Resistance to PD-1 Checkpoint Blockade for Cancer Immunotherapy
The PD-1 pathway delivers inhibitory signals that function as a brake for immune responses and has wide-ranging immunoregulatory functions. This pathway regulates the critical balance between stimulatory and inhibitory signals needed for effective immune responses to microbes and tumors, as well self-tolerance. The critical role of PD-1 in limiting anti-tumor immunity is demonstrated by the transformative effects of PD-1 cancer immunotherapy. Although PD-1 pathway inhibitors are revolutionizing cancer treatment, mechanistic insights are needed to understand why PD-1 pathway blockade works or fails in order to identify responders to PD-1 cancer immunotherapy and to develop rational combination therapies. This talk will discuss studies in mouse models that have identified mechanisms by which the PD-1 pathway regulates anti-tumor T cell responses, and gene perturbation approaches to discover new cancer immunotherapy targets and their mechanisms of action.
서울대학교 자연과학대학